KPV
The last three amino acids of alpha-MSH. It calmed gut inflammation in mouse colitis models; no human trials.
- Evidence
- Primarily preclinical research
- Half-life
- Not known
- Sources
- 2 cited
Is KPV FDA-approved?
Not approved by the FDA. Products sold online as "research chemicals" aren't checked for purity, sterility or dose.
Overview
KPV is the tail end of alpha-MSH, a hormone with anti-inflammatory effects. In mice with colitis, KPV taken by mouth was absorbed by gut cells and reduced inflammation. It hasn't been studied in published human trials.
How it works
Gut cells take it up through the PepT1 transporter; inside, it dampens NF-κB, a master switch for inflammation.
How long does KPV stay in the body?
Not established in people.
What it's studied for
- Inflammatory bowel disease (mice)
- Skin inflammation (cells)
Related: Thymosin Alpha-1, LL-37, FOXO4-DRI, VIP (Vasoactive Intestinal Peptide).
Sources
The studies and prescribing labels this page is written from.
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 2008 PubMed
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of IBD. Inflamm Bowel Dis, 2008 PubMed
