Glutathione
The body's main built-in antioxidant. IV and injected forms are popular for skin lightening and "detox," but human evidence is small.
- Evidence
- Limited human research
- Half-life
- Minutes
- Sources
- 3 cited
Is glutathione FDA-approved?
Sold as a supplement; injectable forms come from compounding pharmacies. Not an FDA-approved drug.
Overview
Glutathione is a three-amino-acid molecule every cell makes to neutralize free radicals and help the liver process toxins. A 6-month trial found oral glutathione raised body stores. Small trials suggest it may slightly lighten skin. Evidence for IV or injected glutathione is weak, and regulators in some countries have warned against IV use for skin whitening.
How it works
It donates electrons to neutralize free radicals and helps enzymes that tag toxins for removal.
How long does glutathione stay in the body?
Minutes in the blood after an IV dose.
What it's studied for
- Antioxidant levels
- Skin lightening
- Liver support
Reported side effects
- Injection-site reactions
- Rare allergic reactions with IV use
Related: MIC (Lipotropic Injection), Vitamin B12, Matrixyl, Argireline.
Sources
The studies and prescribing labels this page is written from.
- Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr, 2015 PubMed
- Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study. J Dermatolog Treat, 2012 PubMed
- The clinical effect of glutathione on skin color and other related skin conditions: a systematic review. J Cosmet Dermatol, 2019 PubMed
